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A Cup of Coffee Every Day May Lower the Risk of Liver Cancer

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Finally, some respite for caffeine lovers! Your daily cup of coffee may not be as bad as you have been told.

A new study, published in the journal BMJ Open, suggests that a your daily dose of coffee can help prevent the risk of liver cancer by nearly 50 per cent. For the longest time, coffee has been regarded as a villain primarily because of its high caffeine content. Caffeine is a central nervous system (CNS) stimulant that is responsible for perking you up and giving you an instant boost of energy on drinking coffee. It is also present in other beverages like energy drinks.

A lot of previous studies have indicated that too much consumption of caffeine may cause an upset stomach, indigestion, high blood pressure, increased heart rate and anxiety. However, this new study suggests that one cup of coffee daily may actually be good for you. 

For the study, researchers from the University of Southampton and the University of Edinburgh universities examined data from 26 previous studies that involved more than 2.25 million participants. The results showed that people who drank one cup of coffee daily had a 20 per cent lower risk of developing the most common type of liver cancer known as hepatocellular carcinoma. Further, they found that those who drank two cups of coffee daily had a 35 per cent reduced risk of suffering the disease while drinking five cups cut their risk by half. Decaffeinated coffee may also be able to lend similar benefits but its effect was very small in comparison to regular coffee.

The researchers are not suggesting that everyone should start consuming lots of coffee every day but they found a link and more study is required to strengthen the evidence that shows positive effects of moderate consumption of coffee. When consumed in moderation, coffee may act as a ‘wonderful natural medicines’, they say. They are still working on trying to find why coffee has a liver cancer-protective effect. Drinking coffee has also been linked to better heart health and increased mental alertness. 

We know that moderation is the key but how much is too much? According to the US FDA, 400 to 500 milligrams of coffee consumption per day is considered to be ‘safe’ (that’s almost 4 cups). However, the effects may vary from person to person. Excess coffee consumption can have side effects like stomach pain, diarrhea, acid reflux, insomnia and restlessness. If you’ve been experiencing any of these frequently for a long time, it’s time to cap your coffee intake.  Bangalore-based Nutritionist, Dr. Anju Sood does caution us and suggests,”Drinking one or two cups of coffee may be fine but if you exceed that it may cause dehydration in your body. In that case, the essential water soluble minerals and vitamins are also flushed out of the body. Therefore, you must stick to your daily dose and combine it with other fluids like warm herbal teas, fresh juices or buttermilk to keep yourself hydrated all day,”

Source: http://food.ndtv.com/health/a-cup-of-coffee-every-day-can-lower-the-risk-of-liver-cancer-1703890

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Liver Cancer: A new method for identifying splicing biomarkers developed

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Turns out, a new method has identified splicing biomarkers for liver cancer. According to a Cold Spring Harbor Laboratory-study, researchers have developed a method for identifying splicing-based biomarkers for the most common form of liver cancer, hepatocellular carcinoma (HCC).

The researchers, led by Professor Adrian Krainer, believed the method will be useful in other cancer types as well. Since, liver cancer is particularly diverse, genetically, and prone to relapse, identifying biomarkers that can predict disease progression is a critical goal in the fight against it.

“This study underscores the potential for learning how RNA splicing variants can contribute to cancer and points to these variants as potential biomarkers for cancer progression,” Krainer said. Splicing refers to a process in which an RNA message copied from information encoded in a gene is edited before it is able to serve as a blueprint for the manufacture of a specific protein.

A gene can give rise to multiple RNA messages, each resulting in a different protein variant, or “isoform.” Many diseases have been associated with errors or variations in the way that RNA is spliced. Errors or variations in splicing can lead to non-functional proteins or proteins with distinct or aberrant functions.

Recent studies have identified splicing irregularities in liver cancer cells. Led by researcher Kuan-Ting Lin, Krainer’s team developed a method that comprehensively analyzes all RNA messages made from a given gene. The team tested their splicing-variant detection method in HCC, by analysing RNA messages in HCC cells sampled from hundreds of patients.

They found that particular splicing isoforms of the gene AFMID correlated with very poor patient survival. These variants lead cells to manufacture truncated versions of the AFMID protein. These unusual versions of the protein are associated with adult liver cancer cells with mutations in tumour-suppressor genes called TP53 and ARID1A.

These mutations, the researchers hypothesised, are associated with low levels of a molecule called NAD+ that is involved in repairing damaged DNA. Restoring missing portions, called exons, to AFMID’s normal RNA message, they proposed, might raise NAD+ to normal levels, avoiding mutations in TP53 and ARID1A.

The team hopes to use small molecules called ASOs (antisense oligonucleotides) that can bind to RNA, to change the way AFMID’s RNA messages are spliced. Krainer’s team previously used this technique to correct errors in the splicing of the gene SMN2 as a way to treat spinal muscular atrophy (SMA).

Fixing AFMID splicing could lead to enhanced production of NAD+ and an increase in DNA repair. “If we can do this, AFMID splicing can become a therapeutic target and the source of a new drug for liver cancer,” Lin said.

Source: https://www.hindustantimes.com/health/liver-cancer-a-new-method-for-identifying-splicing-biomarkers-developed/story-AfcNZSQyt2KGi2BEoWvatM.html

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